Wellbutrin and jaw clenching

Certain medications and drugs act on the brain by stimulating it. The results suggest brain stimulation is believed to contribute to grinding. Scientific data shows several neurotransmitters are involved in the effect of various drugs on bruxism. The dopaminergic systems in the striated wellbutrin and jaw clenching and the frontal lobe of the brain are of special importance, since hyperactivity generates bruxism, particularly the mandibular movement with tooth grinding.

Objective: To report a case of acute dystonia consisting of neck stiffness, trismus, and unilateral temporomandibular joint TMJ pain and subluxation secondary to an increase in sustained-release SR bupropion. Case summary: A year-old white man with a history of chronic low-back pain and tension headaches, taking no other medications, was started on bupropion SR mg once a day for depression. The dosage was increased to mg SR twice a day and eventually augmented with buspirone 15 mg 3 times a day. He developed bilateral trismus, inability to rotate his head laterally, and spontaneous left TMJ subluxation. Symptoms recessed with discontinuation of both medications and failed to reappear with a trial of buspirone 15 mg 3 times a day alone. A retrial of bupropion alone evidenced no adverse effects at a dosage of mg SR once a day. However, when the dosage was increased to mg SR twice a day, the patient reexperienced initial signs of neck stiffness, jaw muscle tightness, and left TMJ subluxation within hours.

Wellbutrin and jaw clenching

Why do SSRIs cause jaw clenching? While the exact mechanism is unknown, it appears that SSRIs trigger jaw clenching because of their effect on the level of neurotransmitters like serotonin in the brain. These neurotransmitters control mood, but they also contribute to movement regulation. Recent clinical evidence points to a significant association between selective serotonin reuptake inhibitor SSRI antidepressant drugs and jaw clenching. The effect is not permanent, as SSRI jaw clenching starts around 3 weeks after starting the medication and resolves 3 weeks after stopping. In a article in the journal BMC Psychiatry, researchers found that compared to all other medications, your chances of reporting bruxism when taking antidepressants are 10 times higher than they are with any other type of medication. The same researchers compared the classes of antidepressant drugs to see which were more closely associated with bruxism. The two related classes of antidepressants with the strongest association with clenching were the SSRIs and the serotonin-norepinephrine reuptake inhibitors SNRIs. Out of these, Zoloft, Celexa, and Trintellix had a statistically significant association with bruxism, according to the study parameters. In the same article, researchers compared three different classes of antidepressants to see their relationship with jaw clenching. Please note that any medication changes should be directed by a healthcare professional. The mechanisms between SSRIs and jaw clenching are poorly understood. Serotonin, norepinephrine, and dopamine are all neurotransmitters that determine your mood. Antidepressant drugs like SSRIs and SNRIs try to improve depression or anxiety disorders by altering the levels of these neurotransmitters in your brain.

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We are incredibly fortunate to live in a time when some of our most painful and debilitating medical conditions can be well-controlled with prescription medications, allowing us to enjoy a more pleasurable quality of life. Jaw pain is a common complication that many people experience as the result of taking certain prescription medications for the treatment of other health conditions. Technically known as TMJ disorder, clenching and gritting the teeth can sometimes be triggered by the medications that are used to treat:. A number of medications that are used to treat these conditions can also trigger jaw problems, including:. These medications have been shown to lead to the unconscious habit of clenching or grinding the teeth, especially at night.

Our pharmacist answers the latest question regarding what to do if your SSRI causes jaw clenching. I'm on citalopram 40mgs daily, bupropion sr mgs daily, hydroxyzine 25mgs 3x daily, trazodone mgs nightly. Can any of one of these medications be a side affect causing my jaw to lock up. If so which one. My dentist said I only open 20 centimeters and it is not a dental issue. While not common, jaw clenching, grinding of teeth and a general condition known as bruxism CAN be caused by some of the medications you are taking including citalopram, trazodone and Wellbutrin. It is most commonly associated with the SSRI selective serotonin reuptake inhibitor you are taking, Celexa. Bruxism is characterized by clenching, grinding of the teeth and difficulty opening and closing the jaw. It most often occurs during sleep, but can really occur at any time of day. Bruxism may also present with complaints of headache, pain in the jaw muscles, decreased range of motion in the jaw, and dental problems indicative of tooth damage.

Wellbutrin and jaw clenching

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:.

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The causes of bruxism are poorly understood, and often related to emotional stress. Dextroamphetemine Sulf-Saccharate — Prescribed for concentration, focus and fidgeting. The above data suggest that the addition of buspirone 5—10 mg up to 3 times daily may be an effective first-line option for alleviating antidepressant-associated bruxism, particularly in patients who may not tolerate dose reduction or medication cessation. The problem is that beyond affecting your mood, these neurotransmitters also facilitate movement. Publication bias limits the true number of cases available in the literature for review, and therefore other offending agents or treatments may have been observed by others that are not represented here. This has not yet been validated in large studies. Hum Psychopharmacol ; 10 — J Neuropsychiatry Clin Neurosci ; 19 — Despite the notion of bruxism being a behavioral phenomenon, there are several case reports and series describing a possible relationship between bruxism and serotonergic antidepressants, including selective serotonin reuptake inhibitors SSRIs and serotonin—norepinephrine reuptake inhibitors SNRIs. Antidepressant-induced bruxism: need for buspirone? Symptoms may begin within 3—4 weeks of medication initiation and may resolve within 3—4 weeks of drug discontinuation, addition of buspirone, or substitution with another pharmacologic agent.

Temporomandibular joint disorder TMD is a broad pain disorder that refers to several conditions affecting the temporomandibular joint of the jaw and the muscles of mastication. As with most pain disorders, a high prevalence of depression and anxiety is associated with TMD. Research has shown that selective serotonin reuptake inhibitors SSRIs , the first-line drug therapy for major depressive disorder, may not be suitable for TMD patients because SSRIs can induce teeth-grinding, otherwise known as bruxism.

Selective Serotonin Reuptake Inhibitors SSRIs — Prescribed for depression, obsessive-compulsive disorder, anxiety, panic disorder, post-traumatic stress disorder, seasonal affective disorder, and depressive episodes of bipolar disorder, social phobia, premenstrual dysphoric disorder and menopause. Garrett: study concept and design, acquisition of data, analysis and interpretation of data. Brain MRI obtained prior to her referral to neurology was unremarkable. The purpose of this systematic review was to compare clinical features and effective treatment interventions of antidepressant-associated bruxism using patient data from published case reports. Jaw pain and bruxism are common, associated with a wide variety of disorders. This may also explain why buspirone is ineffective in treating idiopathic bruxism. Discussion: Medication-induced focal dystonias usually present with dramatic head most frequently oral-buccal and neck muscle spasm with occasional jaw clenching, bruxism, and TMJ syndrome. These data suggest that age may influence the development of bruxism in the setting of antidepressant use. She had seen multiple providers for these symptoms, including orofacial pain and dentistry. The same researchers compared the classes of antidepressant drugs to see which were more closely associated with bruxism.