Tetrahydroquinoline

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Maurya, O. Patel, D. Anand and P. Yadav, Org. To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page. If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

Tetrahydroquinoline

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. IN connexion with work on tetrahydroquinoline derivatives of medicinal interest, we have recently synthesized a number of alkoxy- and alkyl-substituted 1,2,3,4-tetrahydroquinolines 1 in which various dialkylaminoalkyl groups carrying in some cases heterocyclic residues such as morpholino, piperidino, etc. Among the compounds tested so far, N -[2- 4-morpholino ethyl]1,2,3,4-tetrahydroquinoline I has shown interesting biological activity. Aisha Y. Hassan, Sara N. Shabaan, … Eman S. Thyagarajan, G.

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Products Items of N- 1,2,3,4-Tetrahydroquinolinecarbonothioyl benzamide. TM Get our latest updates. We use cookies on our website. Some of them are essential, while others help us to improve this website and your experience. Essential Statistics External Media. Accept All Save.

Tetrahydroquinoline is an organic compound that is the semi-hydrogenated derivative of quinoline. It is a colorless oil. Substituted derivatives of tetrahydroquinoline are common in medicinal chemistry. Tetrahydroquinolines are produced by hydrogenation of quinolines. Because the hydrogenation is reversible, tetrahydroquinoline has been often examined as a hydrogen-donor solvent in coal liquifaction.

Tetrahydroquinoline

Federal government websites often end in. The site is secure. A review of the recent literature is given focusing on synthetic approaches to 1,2,3,4-tetrahydroquinolines, 2,3-dihydro-4 1 H -quinolinones and 4 1 H -quinolinones using domino reactions. These syntheses involve: 1 reduction or oxidation followed by cyclization; 2 S N Ar-terminated sequences; 3 acid-catalyzed ring closures or rearrangements; 4 high temperature cyclizations and 5 metal-promoted processes as well as several less thoroughly studied reactions. Each domino method is presented with a brief discussion of mechanism, scope, yields, simplicity and potential utility. Domino reactions, also known as tandem or cascade reactions, have emerged as a highly effective strategy for the synthesis of bioactive natural products and pharmaceutical agents [ 1 ]. These methods enable chemists to perform complex synthetic conversions with high efficiency using simple starting materials, often via a biomimetic pathway [ 2 ]. Thus, domino reactions contribute immensely to synthetic drug design strategies, enhance aesthetic approaches in total synthesis, and improve yields in large-scale synthesis [ 1 , 2 ]. The advantages of these methods include excellent atom economy, high selectivity, and less waste [ 3 , 4 ]. Additionally, using these strategies, multiple transformations can be carried out in a single laboratory operation without the isolation of intermediates making them prime examples of green chemistry [ 5 , 6 ].

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Nandi, P. Syringes and Needles. A boronic acid catalyzed one-pot tandem reduction of quinolines to tetrahydroquinolines followed by reductive alkylation with a carbonyl compound provides N -alkyl tetrahydroquinolines in the presence of Hantzsch ester under mild reaction conditions. Zhang, Y. Jeon, C. Fujita, L. Laboratory Balances. Help your fellow customer. Please enable JavaScript to access the full features of the site or access our non-JavaScript page. Quinoline , Tetralin , Chromane.

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Structure Search Print. Jump to site search. About us. Yang, Org. Additional Information Tags 0 Reviews 0 Questions 0. Sorry, a shareable link is not currently available for this article. Centrifuge Buckets. No offer available. Thyagarajan, G. The organoboron catalysts behave as both Lewis acids and hydrogen-bond donors. S2CID Signal word.