Reticulocyte production index formula

The reticulocyte production index RPIalso called a corrected reticulocyte count CRCis a calculated value used in the diagnosis of anemia.

Determines the reticulocyte index production RPI based on reticulocyte count, hematocrit or hemoglobin through two different methods. In the text below the calculator there is more information on the two determination methods and an RPI interpretation. The reticulocyte index uses the percentage of immature red blood cells and either haemoglobin or haematocrit to determine the reticulocyte production index. This can offer complete information about the composition of RBCs in terms of cells at all stages of maturation. RPI is used in assessing the response to anemia, especially in patients diagnosed with Sickle Cell disease.

Reticulocyte production index formula

The Reticulocyte production index RPI, also called a corrected reticulocyte count is a calculated value used in the diagnosis of anemia. This calculation is necessary because the raw reticulocyte count is misleading in anemic patients. The problem arises because the reticulocyte count is not really a count but rather a percentage: it reports the number of reticulocytes as a percentage of the number of red blood cells. In anemia, the patient's red blood cells are depleted, creating an erroneously elevated reticulocyte count. Source: Wikipedia. They develop and mature in the bone marrow and then circulate for about a day in the blood before developing into mature RBC. Like mature RBC, reticulocytes do not have a nucleus. They are called reticulocytes because of a reticular mesh-like network of ribosomal RNA that is visible under a microscope. Reticulocytes appear slightly bluer than other RBC when stained with Romanowsky stain. Reticulocytes are also slightly larger and thus can be identified as a high mean corpuscular volume during a full blood count done by machine.

All Rights Reserved. Purpose Formulas Jump To. The reticulocyte production index RPIalso called a corrected reticulocyte count CRCis a calculated value used in the diagnosis of anemia.

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Reticulocyte production index formula

Determines the reticulocyte index production RPI based on reticulocyte count, hematocrit or hemoglobin through two different methods. In the text below the calculator there is more information on the two determination methods and an RPI interpretation. The reticulocyte index uses the percentage of immature red blood cells and either haemoglobin or haematocrit to determine the reticulocyte production index. This can offer complete information about the composition of RBCs in terms of cells at all stages of maturation. RPI is used in assessing the response to anemia, especially in patients diagnosed with Sickle Cell disease.

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Article By: Denise Nedea. A single click install to embed it into your pages, whenever you need to use it. Marrow defects include nutritional deficiencies i. Category : Blood tests. Hemoglobin Hematocrit Red blood cell count Red blood cell indices Mean corpuscular hemoglobin Mean corpuscular hemoglobin concentration Mean corpuscular volume Red blood cell distribution width White blood cell count White blood cell differential Absolute neutrophil count Platelet count Mean platelet volume Reticulocyte count Reticulocyte index. McGraw Hill New York , Harrison's Principles of Internal Medicine. This can offer complete information about the composition of RBCs in terms of cells at all stages of maturation. Fourth Edition Blackwell Science Oxford , The problem arises because the reticulocyte count is not really a count but rather a percentage: it reports the number of reticulocytes as a percentage of the number of red blood cells.

The reticulocyte production index RPI , also called a corrected reticulocyte count CRC , is a calculated value used in the diagnosis of anemia. This calculation is necessary because the raw reticulocyte count is misleading in anemic patients. The problem arises because the reticulocyte count is not really a count but rather a percentage : it reports the number of reticulocytes as a percentage of the number of red blood cells.

Below is a sample of the possible capabilities. Calculated value in diagnosis of anemia. The RPI is the corrected reticulocyte count which accounts for all reticulocytes in all development stages. Next Review: June 7, J Clin Diagn Res. The reticulocyte production index is most often used in the diagnosis of anemias. Retrieved Close Click to copy. The RPI is used to assess whether the bone marrow is producing an appropriate response to an anemic state. Certain staining techniques cause components of the ribosomes to precipitate into characteristic "reticulum" not the same as the endoplasmic retuculum , hence the name reticulocytes. Values greater than 3, when accompanied by anemia, indicate RBC loss but an increased production of reticulocytes. RPI calculator 2. This calculation is necessary because the raw reticulocyte count is misleading in anemic patients. Like mature RBC, reticulocytes do not have a nucleus.