Peroxynitrite

Federal government websites often end in. The peroxynitrite is secure, peroxynitrite. Peroxynitrite is the peroxynitrite of the diffusion-controlled reaction of nitric oxide and superoxide radicals. Peroxynitrite, a reactive short-lived peroxide with a p K a of 6.

Peroxynitrite can be prepared by the reaction of superoxide with nitric oxide : [1] [2] [3]. It is prepared by the reaction of hydrogen peroxide with nitrite : [4]. It is reactive toward DNA and proteins. It is these radicals carbonate radical and nitrogen dioxide that are believed to cause peroxynitrite-related cellular damage. Its conjugate acid peroxynitrous acid is highly reactive, although peroxynitrite is stable in basic solutions. Contents move to sidebar hide. Article Talk.

Peroxynitrite

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Similarly, NX indicated an uncharacterized nitrogen-containing product, peroxynitrite, later proved to be nitrite.

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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. The second goal of the article is to outline the therapeutic implications of peroxynitrite, and to give an overview of the various pharmacological classes of peroxynitrite scavengers and peroxynitrite decomposition catalysts.

Peroxynitrite

Federal government websites often end in. The site is secure. General Flores , Montevideo , Uruguay. In this review we provide an analysis of the biochemistry of peroxynitrite and tyrosine nitration. In addition, peroxynitrite anion can secondarily evolve to secondary radicals either via its fast reaction with CO 2 or through proton-catalyzed homolysis. Peroxynitrite can cause protein tyrosine nitration in vitro and in vivo. Protein tyrosine nitration can mediate changes in protein structure and function that affect cell homeostasis.

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H American Journal of Physiology. Hausladen A. The last three listed compounds are examples of synthetic molecules utilized to either decompose or detect peroxynitrite. In the case of microbial systems, peroxiredoxins have been recently revealed as virulence factors due to their capacity to detoxify peroxynitrite formed from macrophages both in vitro and in vivo 72 , S; Liaudet, L Implications for microbial killing. Castro L. A large number of compounds have been used with pharmacological goals to cope with the toxic effects of peroxynitrite and peroxynitrite-derived radicals Reduced MnP can also eliminate peroxynitrite-derived carbonate radicals Table 1

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In other projects. Zhu L. Bringold U. Peroxynitrite-dependent Cytotoxicity The reactions of peroxynitrite with biomolecules can led to cytotoxic events, which may result in apoptotic or necrotic cell death 54 , 70 , The direct reaction is relatively slow, so protection is ascribed to reaction with peroxynitrite-derived radicals. Glutathione b It evolves mainly to glutathione disulfide through the intermediacy of glutathione sulfenic acid Pfeiffer S. The participation of peroxynitrite in pathophysiological conditions has been recognized in cellular and animal disease models and in human pathology 54 , Microbial and mammalian peroxiredoxins constitute a central catalytic mechanism for the detoxification peroxynitrite. Oxyhemoglobin 2.