Paul insel

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Paul insel

Current work emphasizes GPCR expression by individual cell types and the contribution of particular GPCRs to cellular responses, in particular, in cells especially cancer cells and cancer-associated fibroblasts in the tumor microenvironment. We focus on previously unrecognized GPCRs as regulators of cell function and as novel therapeutic targets. Our current emphasis is on pancreatic cancer. Other efforts include the identification of therapeutic approaches for patients with COVID based on its pathobiology in the hosts. Front Pharmacol. Insel PA. PLoS Biol 17 11 :e Brit J Pharmacol. Proton-sensing G protein-coupled receptors: detectors of tumor acidosis and candidate drug targets. Future Med Chem Sriram K, Insel PA.

Forskolin requires more than the catalytic unit to activate adenylate cyclase.

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Paul insel

Current work emphasizes GPCR expression by individual cell types and the contribution of particular GPCRs to cellular responses, in particular, in cells especially cancer cells and cancer-associated fibroblasts in the tumor microenvironment. We focus on previously unrecognized GPCRs as regulators of cell function and as novel therapeutic targets. Our current emphasis is on pancreatic cancer. Other efforts include the identification of therapeutic approaches for patients with COVID based on its pathobiology in the hosts. Front Pharmacol. Insel PA. PLoS Biol 17 11 :e Brit J Pharmacol.

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Increase in cellular cyclic AMP concentrations reverses the profibrogenic phenotype of cardiac myofibroblasts: a novel therapeutic approach for cardiac fibrosis. Zhang L , Insel PA. Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitors. Considering and reporting sex as an experimental variable II: An update on progress in the British Journal of Pharmacology. Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein IAP AJP-Cell begins a theme series on tissue fibrosis. Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase. Purinergic Signalling. Experimental Cell Research. Replacement of serum with a defined medium increases beta-adrenergic receptor number in cultured glioma cells. Concepts Relationships between membrane cholesterol, alpha-adrenergic receptors, and platelet function. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolinassociated microdomains in adult cardiac myocytes.

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Home Contact us. Historical perspectives in cell physiology: looking back to help the discipline move forward. Levi M, Insel PA. Other efforts include the identification of therapeutic approaches for patients with COVID based on its pathobiology in the hosts. PMID PLoS Biol 17 11 :e Kidney Int. Adenylate cyclase 6 determines cAMP formation and aquaporin-2 phosphorylation and trafficking in inner medulla. Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase. Protein kinase C isozymes and the regulation of diverse cell responses. BJP recommendations for publishing research on tobacco smoke and environmental tobacco smoke exposure. J Hum Genet. The Journal of Biological Chemistry. British journal of pharmacology 2 , , Considering and reporting sex as an experimental variable II: An update on progress in the British Journal of Pharmacology.