Ondansetron drug interactions

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Ondansetron belongs to the class of medications called 5-HT3 receptor antagonists. This medication is used to prevent nausea and vomiting associated with certain types of cancer chemotherapy and radiation. It is also used to prevent and treat the nausea and vomiting that occurs after surgery. It works by reducing the effects of a naturally-occurring chemical in the body called serotonin, which causes nausea and vomiting. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here. Your doctor may have suggested this medication for conditions other than those listed in these drug information articles.

Ondansetron drug interactions

Purpose: Both ondansetron and cyclophosphamide are thought to be metabolized by hepatic microsomal processes. The purpose of this study was to evaluate the potential pharmacokinetic interactions between ondansetron and high-dose alkylating agent chemotherapy. Methods: A total of 54 breast cancer patients receiving high-dose cyclophosphamide, cisplatin and carmustine were treated prospectively in four sequential cohorts. Cohorts I and II received continuous infusions of both ondansetron and prochlorperazine, and cohorts III and IV received a continuous infusion of ondansetron alone at the same doses. All patients received lorazepam every 4 h. A group of 75 matched historical controls had received a continuous infusion of prochlorperazine with lorazepam. Pharmacokinetic monitoring of each drug used in the high-dose chemotherapy regimen was conducted. Results: Median AUCs of cyclophosphamide in patients receiving ondansetron Patients treated with ondansetron displayed a higher frequency of headaches than the controls. Conclusion: Ondansetron altered the systemic exposure to cyclophosphamide when these agents were administered concomitantly. Ondansetron did not substantially improve overall emetic control when used alone but may improve control in combination with prochlorperazine. Future randomized studies are needed to delineate the effect of ondansetron on the disposition of the active cyclophosphamide metabolites so that clinical implications can be addressed. Abstract Purpose: Both ondansetron and cyclophosphamide are thought to be metabolized by hepatic microsomal processes. Gov't Research Support, U.

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Ondansetron is a medicine used to prevent nausea and vomiting caused by surgery or cancer treatments. Ondansetron works by blocking serotonin, a natural substance in the brain that can trigger nausea and vomiting. The U. Ondansetron is not expected to harm an unborn baby. Tell your doctor if you are pregnant.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Appropriate studies have not been performed on the relationship of age to the effects of ondansetron in children younger than 4 years of age.

Ondansetron drug interactions

Key takeaways Drug interactions Food interactions Other interactions Avoiding interactions When to see a doctor. Ondansetron , known under the brand name Zofran , is a selective 5-HT3 receptor antagonist that functions as an antiemetic to aid in the prevention of nausea and vomiting from chemotherapy or radiation therapy , treatment of severe and acute nausea and vomiting and the prevention and treatment of postoperative nausea and vomiting. Ondansetron is available as an injection, an oral solution, an oral tablet, and an orally-disintegrating tablet. Ondansetron interactions with amiodarone, domperidone, methadone, specific antiarrhythmic and antibiotic medications, and serotonergic agents. Ondansetron can also affect the metabolism of other medicines, exacerbating side effects associated with individual drugs.

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Bambuterol is predicted to cause hypokalaemia potentially increasing the risk of torsade de pointes when given with Ondansetron. The side effects listed below are not experienced by everyone who takes this medication. Check with your doctor right away if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there. As well, some forms of this medication may not be used for all of the conditions discussed here. The most serious medications that ondansetron interferes with include certain antiarrhythmics, antibiotics, and serotonergic medications. Do not take a double dose to make up for a missed one. Concomitant use of ondansetron and apomorphine can lead to profound hypotension and loss of consciousness, with ondansetron enhancing the hypotensive effects of apomorphine. For non-prescription products, read the label or package ingredients carefully. Use Ondansetron Zofran exactly as directed on the label, or as prescribed by your doctor. Help Accessibility Careers. To take the Zofran ODT : orally disintegrating tablet.

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If you have liver disease or reduced liver function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Both Ondansetron and Citalopram prolong the QT interval. Ivabradine is predicted to increase the risk of torsade de pointes when given with Ondansetron. Bumetanide is predicted to cause hypokalaemia potentially increasing the risk of torsade de pointes when given with Ondansetron. If someone collapses or isn't breathing after taking Ondansetron Zofran , call Tapentadol is predicted to increase the risk of serotonin syndrome when given with Ondansetron. Both Ondansetron and Pazopanib prolong the QT interval. What to Expect Ondansetron usually starts to work within about 30 minutes. The combination of ondansetron and other 5HT3 antagonists, including granisetron , dolasetron , and palonosetron, are contraindicated with apomorphine , given the risk of enhanced hypotensive effects. Both Ondansetron and Glasdegib prolong the QT interval. Patients prescribed ondansetron , especially those at higher risk for cardiac abnormalities, such as those with heart failure or electrolyte abnormalities including blood potassium and magnesium levels , should be monitored with an EKG before receiving the first dose. Vitamin C and Adderall interactions Feb. If vomiting continues, check with your doctor. Primidone is predicted to decrease the exposure to Ondansetron.