Macquarie university dementia research centre

The past decades of drug development have focused on clearing amyloid or reducing its formation but unfortunately have all failed to deliver. Hence, there is an unmet need for new therapeutic avenues in dementia.

Lars graduated from the University of Ulm in Germany and completed his thesis at the University … View full profile. Yuanyuan completed a PhD in Biomedical Science in Currently a Postdoctoral Fellow at Macquarie University in the Dementia Research Centre, focusing on the pathogenesis of Alzheimer's disease and related gene-target therapy. Previously working as a researcher and lecturer at the Key Laboratory … View full profile. Seonghee worked as a postdoctoral fellow at DGIST where her work focused on investigating the pathogenic mechanism… View full profile. Andrea is a research assistant responsible for histology and tissue processing at the Dementia Research Centre, Faculty of Medicine and Health Science. Emily is currently a PhD candidate with the Dementia Research Centre focusing on inhibitory interneurons in Alzheimer's disease.

Macquarie university dementia research centre

The DRC currently includes eight research groups. The teams at the Dementia Research Centre currently have more than 10 different therapeutic development programs at different stage of pre-clinical testing. These include small molecules, antibodies and gene therapy approaches. Most of these proprietary molecules and drug targets are based on novel discoveries of disease mechanisms made over the past decade. AAVs are particularly well suited for gene delivery into cells and living organisms, including for gene therapy in humans. Operating our own AAV core allows immediate access to this cutting-edge technology for all our research teams, accelerating multiple discovery research projects and our gene-therapy pipeline. Brain neurons remain one of the hardest cell types to culture, due to their inability to multiply and fastidious culturing conditions. Techniques to grow neurons in single layers have long been developed but remain both labour and costs-intensive. At the same time these 2D cultures do not resemble the complexity of the brain. To overcome these limitations, the Dementia Research Centre has brought together experts in cellular neurobiology and peptide hydrogel chemistry and developed new 3D neuronal culture systems, based on our proprietary matrix technology. Learn more about 3D hydrogel culture technologies. The Dementia Research Centre is home to one of the largest colonies of genetically modified mouse models of dementia in Australia.

Here, the team of the Dementia Research Centre has made fundamental discoveries that shed new light on the causes of dementia. These models need to accurately recapitulate aspects of the human conditions and at the same time be assessible for experimental manipulation. Research output per year.

Please also feel free to contact us if you are not eligible for any of the studies below, or if you have any suggestions or questions. We will keep you in mind for our next study or put you in contact with other researchers who may be able to help you. You will also do some cognitive tests, answer questionnaires, provide a blood sample and have some body measurements taken. You may chose to have an optional lumbar puncture to collect cerebral spinal fluid CSF. After that you will receive information on studies you are eligible for and you can decide if you would like to participate. If you would like to volunteer, please contact the team at: E: adnet. Previous work by Professor Ralph Martins and his team has found that the effects of testosterone therapy may extend to both the accumulation and clearance of amyloid beta from the brain and may potentially prevent the disease.

View more. The researcher will also integrate into ongoing research projects focusing on understanding disease mechanisms in dementia. The role will involve administering and testing novel gene therapies in a range of mouse models for various neurological disorders including epilepsy and dementia , as well as further developing and testing novel gene therapies in various cell culture systems. The role requires significant independence in experimental planning and execution, data analysis and reporting. The successful candidate will present the data at scientific conferences and contribute to the preparation of manuscripts towards publications in scientific journals.

Macquarie university dementia research centre

Hope: Professor Lars Ittner, who has spent 15 years working on unravelling the mysteries of dementia, feels his goal of developing effective drug therapies is now achievable thanks to the team assembled at the new Dementia Research Centre. But Professor Lars Ittner says, for the first time in over 15 years of working to develop drugs for this debilitating disease, effective therapies are now within his grasp. Professor Ittner has brought his research partners from his previous role at the University of NSW with him, and recruited widely to gather a crack team who are already immersing themselves in their mammoth task. He says that Macquarie was an obvious choice because of its existing network of neuroscience research. Professor Ittner says that for at least the next five years, the Centre will focus on pre-clinical dementia research and drug development. The Centre has seven different teams specialising in very different aspects of research, from genome editing to chemistry to new cellular models of disease.

Moving trucks indianapolis

Deputy Director Operations and group leader. Previous work by Professor Ralph Martins and his team has found that the effects of testosterone therapy may extend to both the accumulation and clearance of amyloid beta from the brain and may potentially prevent the disease. E-mail: yazi. Tietz group team members. Director and group leader. We examine clinically and pathologically well-characterised human brain tissue from sporadic and genetic neurodegenerative disorders sourced from national and international Brain Banks and Research Institutions, and transgenic models of dementia. E-mail: kanishkapushpitha. Skip to content Skip to navigation. In vivo disease models The Dementia Research Centre is home to one of the largest colonies of genetically modified mouse models of dementia in Australia. View all 32 profiles. Julia van der Hoven completed her Bachelor of Science majoring in physiology and pharmacology at The University of Sydney in You may chose to have an optional lumbar puncture to collect cerebral spinal fluid CSF. E-mail: liming.

Our vision is a world without MND. Our mission is to provide world-class care for people living with MND and to develop new effective treatments for this devastating disease. Our MND clinicians work collaboratively under a robust multidisciplinary team MDT model, which is a well-established, evidence-based treatment approach.

If eligible, you will be asked to undergo more memory testing, brain scans, and other assessments before and after being treated with testosterone and fish oil or a placebo version of one or both for a week period. Would you like to volunteer for a clinical trial? The Dementia Research Centre is home to one of the largest colonies of genetically modified mouse models of dementia in Australia. You will also do some cognitive tests, answer questionnaires, provide a blood sample and have some body measurements taken. He recently joined… View full profile. She then began working a… View full profile. We will keep you in mind for our next study or put you in contact with other researchers who may be able to help you. Together they form a unique fingerprint. Disease mechanisms Press the 'Space' or 'Enter' key to toggle the additional content To treat dementia, it is vital to first understand the processes that lead to neuronal dysfunction and brain atrophy. Here, the team of the Dementia Research Centre has made fundamental discoveries that shed new light on the causes of dementia. E-mail: yazi. She completed her PhD in Bioengineering at the Pukyung National University in the Republic of Korea, identifying and characterized genetic marker related disease resistant in fish model. E-mail: reuben.