Lymphocytic infiltration

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Journal of Translational Medicine volume 11 , Article number: Cite this article. Metrics details. Primary cutaneous lymphomas CLs , characterized by an accumulation of clonal T or B lymphocytes preferentially localized in the skin, have been successfully treated with interferons IFNs which counterbalance the Th2-immunosuppressive state associated with this pathology. For each patient, variation in time of specific lymphocyte populations, defined by immunohistochemical stainings, was assessed in biopsies of injected lesions. The phase I step TG The phase II step TG

Lymphocytic infiltration

Degree of lymphocyte infiltration in 8 specimens with cervical node—positive and 12 specimens with cervical node—negative findings in undifferentiated nasopharyngeal cancer. Bar indicates SE; mpf, medium power-fields. Lymphocytic Infiltration in Undifferentiated Nasopharyngeal Cancer. Arch Otolaryngol Head Neck Surg. Background Undifferentiated nasopharyngeal carcinoma NPC is characterized by prominent lymphocytic infiltration. Although the lymphoid infiltrate in NPC has been examined extensively in morphologic and immunocytochemical studies, the significance of this lymphoid infiltrate and its correlation with prognosis has been a subject of controversy for years. Objective To elucidate the significance of lymphoid infiltration in undifferentiated NPC. Design Evaluation of the relationship between lymphocytic infiltration in NPC and cervical lymph node status, ultrastructural examination of the lymphoid infiltrate, and assessment of lymphocytic infiltration as an independent prognosticator of regional node metastasis. Materials and Methods Lymphocytic infiltration was evaluated quantitatively in 20 cases of undifferentiated NPC using light microscopy. Four cases of undifferentiated NPC were processed for conventional electron microscopy. The effects of degree of lymphocytic infiltration, age, and tumor stage on cervical nodal metastasis were analysed using the logistic regression model. Ultrastructural evidence of lymphocytes destroying cancer cells was seen. Conclusions The lymphoid infiltrate is beneficial in undifferentiated NPC, and its presence may deter regional metastasis of cancer cells to the cervical nodes.

Background Cutaneous lymphoma CLwith an incidence of 1 case perindividuals per year, is a group of at least fifteen rare diseases [ lymphocytic infiltration ].

However, since the original description by Jessner and Kanof in [ 1 ], the existence of JLI as a distinct disease has been questioned [ 2 ]. The list of disorders that overlap clinically and histologically with JLI is vast, indicating that JLI is probably not a separate entity, but rather a clinicopathologic reaction pattern common to different skin diseases [ ]. In the last few decades, significant advancements in the immunopathologic and molecular diagnosis have enabled a specific diagnosis for many of the cases previously labeled as JLI [ ]. Nonetheless, some cases of JLI defy a precise diagnosis. This topic will review the clinical manifestations, diagnosis, differential diagnosis, and management of JLI.

However, since the original description by Jessner and Kanof in [ 1 ], the existence of JLI as a distinct disease has been questioned [ 2 ]. The list of disorders that overlap clinically and histologically with JLI is vast, indicating that JLI is probably not a separate entity, but rather a clinicopathologic reaction pattern common to different skin diseases [ ]. In the last few decades, significant advancements in the immunopathologic and molecular diagnosis have enabled a specific diagnosis for many of the cases previously labeled as JLI [ ]. Nonetheless, some cases of JLI defy a precise diagnosis. This topic will review the clinical manifestations, diagnosis, differential diagnosis, and management of JLI.

Lymphocytic infiltration

This topic will discuss the definition of atypical lymphocytic infiltrate, the difficulties in differentiating reactive lymphocytic infiltrates from early lymphoma from the pathologist and clinician perspective, and the management of patients who receive this ambiguous diagnosis. Mycosis fungoides and other cutaneous lymphoproliferative disorders are discussed separately. Why UpToDate? Learn how UpToDate can help you. Select the option that best describes you. View Topic. Font Size Small Normal Large. Approach to the patient with a diagnosis of atypical lymphocytic infiltrate of the skin.

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Ultrastructural analysis. Required Max. Correspondence to Ronald Rooke. Access through your institution. There is still debate about whether this disease is a unique entity or part of a spectrum of cutaneous diseases, including discoid lupus erythematosus, polymorphous light eruption, and possibly malignant lymphoma. Hum Pathol. Arch Otolaryngol Head Neck Surg. J Cutan Pathol. The concentrations reached induce lymphocytic infiltration and activation of local effector cells [ 16 ]. X Facebook More LinkedIn. I agree to the terms and conditions. Your Email Required. The lesions are arranged in crescents of rings ranging from 2 mm to 2 cm in diameter. Before sharing sensitive information, make sure you're on a federal government site. Formulary drug information for this topic.

Lymphocytic interstitial pneumonia LIP is lymphocytic infiltration of the alveolar interstitium and air spaces.

The presenting symptoms of these patients were decreased hearing, nasal symptoms such as discharge and epistaxis, and respiratory symptoms such as blood-stained sputum. Revelation steps were adapted for each primary antibody and applied for 30 minutes Table 2. Similar results were seen in regressing CTCL tumors after intralesional administration of IL [ 14 ] or after injection with adenovirus-engineered IL-2 expressing autologous plasma cells [ 22 ]. M Lusky and B Acres for critical reading of the manuscript. Am J Surg Pathol. Additionally, it is more prevalent in regions of warmer climate and affects the skin and peripheral nerves. Lastly, for patients using medical therapy such as topical steroids and antimalarials, regular follow-up is required to monitor for side-effects like skin atrophy. Marker-specific primary antibodies and their conditions of use are described in Table 2. Review Eosinophilic folliculitis, eosinophilic dermatosis of hematologic malignancy and acneiform follicular mucinosis: Two case reports and a review of the literature highlighting the spectrum of histopathology. Conclusion In summary, intralesional injections of TG Adenovirus-IFN-g induce changes in the nature of the infiltrate differing from the initial lymphoma. Author information Authors and Affiliations Transgene S. These eruptions, usually located on the face and trunk, have an indolent course before resolving spontaneously or with medical treatment.