Lipoxygenase

Unless otherwise stated all data on this page refer to the lipoxygenase proteins. Gene information is provided for human Hsmouse Mm and rat Rn, lipoxygenase.

Federal government websites often end in. The site is secure. Lipoxygenases LOXs are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. LOX enzymes are expressed in immune, epithelial, and tumor cells that display a variety of physiological functions, including inflammation, skin disorder, and tumorigenesis. In the humans and mice, six LOX isoforms have been known. Many mutations in this isoform are found in epithelial cancers, suggesting a potential link between LOX and tumorigenesis. Defects in this gene result in ichthyosis, a cutaneous disorder characterized by pathophysiologically dried skin due to abnormal loss of water from its epithelial cell layer.

Lipoxygenase

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Lipoxygenases are a family of enzymes which dioxygenate unsaturated fatty acids, thus initiating lipoperoxidation of membranes and the synthesis of signaling molecules. Consequently, they induce structural and metabolic changes in the cell in a number of pathophysiological conditions. Recently, a pro-apoptotic effect of lipoxygenase, and of the hydroperoxides produced thereof, has been reported in different cells and tissues, leading to cell death. Anti-apoptotic effects of lipoxygenases have also been reported; however, this has often been based on the use of enzyme inhibitors. Here we review the characteristics of the lipoxygenase family and its involvement in the initiation of oxidative stress-induced apoptosis. Finally, we discuss the role of lipoxygenase activation in apoptosis of animal and plant cells, suggesting a common signal transduction pathway in cell death conserved through evolution of both kingdoms.

Subcellular localization and tumor-suppressive functions of lipoxygenase 2 LOX2 and its splice variants. You can also search for this author lipoxygenase PubMed Google Scholar. Cytokine inhibitors in rheumatoid arthritis and other autoimmune diseases, lipoxygenase.

Federal government websites often end in. The site is secure. Cancer and inflammation are intimately linked due to specific oxidative processes in the tumor microenvironment. Lipoxygenases are a versatile class of oxidative enzymes involved in arachidonic acid metabolism. An increasing number of arachidonic acid metabolites is being discovered and apart from their classically recognized pro-inflammatory effects, anti-inflammatory effects are also being described in recent years. The identification of the role of arachidonic acid metabolites in several inflammatory diseases led to a significant drug discovery effort around arachidonic acid metabolizing enzymes. However, to date success in this area has been limited.

Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. Lipoxygenases LOXs , naturally occurring enzymes, are widely distributed in plants and animals.

Lipoxygenase

Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October

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Ohgami R. The 5-LOX inhibitor zileuton has been accepted and used successfully for the control of asthma. Tumor-suppressive functions of lipoxygenase-2 and RB1CC1 in prostate cancer. Mabalirajan U. Brooks C. Investigations of human platelet-type lipoxygenase: Role of lipoxygenase products in platelet activation. Garcia-Verdugo I. Generally, substances sharing similarity to either lipids or phenolic antioxidants have lower inhibitory activity for LOX enzyme. An independent study of peritonitis also excluded an intrinsic role for Alox15 during the ingestion of ACs as resolution-phase macrophages from both wild-type and Alox15 knockout mice ingested equally high amounts of ACs Uderhardt et al. Pharmacological intervention with 5-lipoxygenase: New insights and novel compounds.

Lipoxygenases LOXs are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid.

Conrad D. Both enzymes act critically prior to this transglutamination, as previous observations have suggested that a deficiency of 12R-LOX, as well as eLOX-3, causes failure of the skin barrier due to defective formation of enzymatic lipid oxidation products [78—80]. Endogenous LXA4 circuits are determinants of pathological angiogenesis in response to chronic injury. The more compact mammalian enzyme contains only one boot-shaped cavity cavity II. Duroudier N. Recent advances for FLAP inhibitors. These HPETEs are subsequently reduced and transformed to form so called eicosanoids, which are signaling molecules that play an important regulatory role in the immune responses and other physiological processes. The formed foam cells will develop plaques of atheroma and their accumulation in the arteries leads to atherosclerosis. Role of the 5-lipoxygenase-activating protein FLAP in murine acute inflammatory responses. Haining J.