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Objective: In this study, we utilized bibliometric methods to assess the worldwide scientific output and identify hotspots related to the research on the volume-regulated anion channel VRAC from to To analyzed the data, we utilized VOSviewer, a tool for visualizing network, to create networks based on the collaboration between countries, institutions, and authors. Additionally, we performed an analysis of journal co-citation, document citation, and co-occurrence of keywords. Furthermore, we employed CiteSpace 6. R6 Advanced to analyzed keywords and co-cited references with the strongest burst. Results: The final analysis included a total of related articles and reviews, covering the period from to The United States emerged as the leading country contributing to this field, while the University of Copenhagen stood out as the most prominent institution.

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All literature retrieval and record downloads were collected in a single day 22 March to eliminate any potential deviation resulting from daily updates to the database. Identification of key signaling molecules involved in the activation of the swelling-activated chloride current in human glioblastoma cells. Lee vrac J, lee vrac.

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Furthermore, institutions contributed articles to VRAC research. Neuron , — Immunity 52, — Green, J. Check other websites in. Among these countries, the United States boasted the greatest overall link potency, with 56 connections. As depicted in Figure 3C , the United States consistently ranking first in publication output, except for and We conducted an unbiased, objective and comprehensive manner, providing a clear overview of the current status of VRAC research. Stroka, K. Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Zinc pyrithione activates the volume-regulated anion channel through an antioxidant-sensitive mechanism. Zuccolini, P. Swelling-induced chloride current in glioblastoma proliferation, migration, and invasion. Based on our current understanding, this study represents the initial bibliometric analysis examining patterns in VRAC channel research area. Megalencephalic leukoencephalopathy with cysts: The glialcam-null mouse model.

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Through the analysis of keyword co-occurrence, it was discovered that VRAC is involved in various physiological processes including cell growth, migration, apoptosis, swelling, and myogenesis, as well as anion and organic osmolyte transport including chloride, taurine, glutamate and ATP. Konishi, T. Elife 8, e Among these countries, the United States boasted the greatest overall link potency, with 56 connections. Subunit-dependent oxidative stress sensitivity of LRRC8 volume-regulated anion channels. Physiology of cell volume regulation in vertebrates. EMBO Rep. Analysis of keyword co-occurrence. Neuron , — Cell Biol. VRAC is also associated with related ion channels such as TMEM16A, TMEM16F, pannexin, and CFTR, and associated with various diseases including epilepsy, leukodystrophy, atherosclerosis, hypertension, cerebral edema, stroke, and different types of cancer including gastric cancer, glioblastoma and hepatocellular carcinoma. Co-citation analysis map of the journal patterns in VRAC research with over 50 documents. Japan and Italy have relatively stable publication outputs, with no more than 5 papers published annually. Yang, J.