J exp med

Potential mechanisms driving obesity-related inflammation, primarily in adipose tissue and j exp med metabolic organs and implications of circulatory inflammatory factors on various metabolic and regulatory organs. Chromosome 15 15q abnormality in patients with Prader-Willi syndrome and Angelman syndrome. WJEM accepts both solicited and unsolicited manuscripts.

Journal of Experimental Medicine is a monthly peer-reviewed medical journal published by Rockefeller University Press that publishes research papers and commentaries on the physiological , pathological , and molecular mechanisms that encompass the host response to disease. The journal prioritizes studies on intact organisms and has made a commitment to publishing studies on human subjects. The journal has no single editor-in-chief , but thirteen academic editors. Welch , the school's founder and also the first president of the Board of Scientific Directors of the Rockefeller Institute since renamed Rockefeller University. From its inception, Welch edited the journal by himself—even editing manuscripts while attending baseball games.

J exp med

Sign In or Create an Account. Search Dropdown Menu. Advanced Search. User Tools Dropdown. Sign In. Skip Nav Destination. Cancer Immunotherapy Update Lymphatic Vessels in Health and Disease Newest Articles. March 06 IL promotes skin autoinflammation. Autoinflammation is marked by IL-1 cytokine overexpression and excessive infiltration by neutrophils. By studying pustular psoriasis, we identify a cascade where neutrophils release IL and trigger skin autoinflammation. March 05 Liu et al.

Submit Your Research. From its inception, Welch edited the journal by himself—even editing manuscripts while attending baseball games.

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The intestine plays an important role in nutrient digestion and absorption, microbe defense, and hormone secretion. Although major cell types have been identified in the mouse intestinal epithelium, cell type-specific markers and functional assignments are largely unavailable for human intestine. Here, our single-cell RNA-seq analyses of 14, epithelial cells from human ileum, colon, and rectum reveal different nutrient absorption preferences in the small and large intestine, suggest the existence of Paneth-like cells in the large intestine, and identify potential new marker genes for human transient-amplifying cells and goblet cells. We have validated some of these insights by quantitative PCR, immunofluorescence, and functional analyses. Furthermore, we show both common and differential features of the cellular landscapes between the human and mouse ilea. Therefore, our data provide the basis for detailed characterization of human intestine cell constitution and functions, which would be helpful for a better understanding of human intestine disorders, such as inflammatory bowel disease and intestinal tumorigenesis. Abstract The intestine plays an important role in nutrient digestion and absorption, microbe defense, and hormone secretion.

J exp med

Journal of Experimental Medicine JEM is a broad journal that publishes papers providing novel conceptual insight into immunology, cancer biology, vascular biology, microbial pathogenesis, neuroscience, and stem cell biology. We are interested in original findings on all aspects of disease pathogenesis, and we are happy to consider papers reporting novel therapeutic approaches. We strongly encourage submissions of human studies.

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Volume ,. The peripheral activity of anti-PD-1 mAb is not fully understood. Chromosome 15 15q abnormality in patients with Prader-Willi syndrome and Angelman syndrome. All rights reserved. Altered expression of miRa and dysregulated cytokines in systemic lupus erythematosus: Unveiling diagnostic and prognostic markers. The paramount objective of WJEM is to showcase and promote distinguished research in the field of experimental medicine, to help advance development of this field. Journal of Experimental Medicine. In this Review, Freret and Boire describe the anatomy of the leptomeninges and routes of cancer spread to the CSF, highlighting therapeutic opportunities. Lymph node microenvironments support Th2 differentiation. Skip Nav Destination. WJEM accepts both solicited and unsolicited manuscripts. Case Control Study. View This Issue. Advanced Search. Intrathecal VEGF-C pretreatment promotes lymphatic drainage of brain-derived fluids and improves neurological outcomes after ischemic stroke via reduced microglia-mediated neuroinflammation and increased BDNF signaling.

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Welch , the school's founder and also the first president of the Board of Scientific Directors of the Rockefeller Institute since renamed Rockefeller University. March 01 Core Tip. In October , Welch appealed to the board of the Rockefeller Institute to take over the journal. Her lab is interested in understanding the molecular mechanisms underlying the transcriptional, translational, and metabolic mechanisms of the key cell types involved in host defense and inflammatory responses: macrophages and intestinal epithelial cells. Human neutrophils drive skin autoinflammation by releasing interleukin IL Journal of Experimental Medicine. March 07 View This Issue. Zhang et al. By studying pustular psoriasis, we identify a cascade where neutrophils release IL and trigger skin autoinflammation.