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Negatief, positief, neutraal: we zetten een review altijd online. De controles gebeuren automatisch, al kijken er soms mensen mee. Als een reviewer door een andere partij is vergoed, staat dit hrd jassen de review zelf. Ontvang eenmalig een mail of notificatie via de bol, hrd jassen.

Principal Investigators: Paul D. Lorsolo, AIR. Investigate impact of environmental flow, in particular vertical shear, on tropical cyclone inner-core structure, using a combination of case studies and compositing techniques on a variety of observational and modeling datasets. Investigate wind speed asymmetries and their relationship with storm motion and vertical shear using composites of SFMR and flight-level data. Study the relationship between vertical shear and the azimuthal variation of the distributions of reflectivity, vertical velocity, and tangential and radial flow. This work complements the work done by Reasor et al.

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Purpose: The elevated levels of somatic copy-number alterations SCNAs in a subset of high-risk endometrial cancers are suggestive of defects in pathways governing genome integrity. We sought to assess the prevalence of homologous recombination deficiency HRD in endometrial cancers and its association with histopathologic and molecular characteristics. Experimental design: Fresh tumor tissue was prospectively collected from 36 endometrial cancers, and functional HRD was examined by the ability of replicating tumor cells to accumulate RAD51 protein at DNA double-strand breaks RAD51 foci induced by ionizing radiation. Conclusions: HRD occurs in endometrial cancers and is largely restricted to non-endometrioid, TP53 -mutant endometrial cancers. Evaluation of HRD may help select patients that could benefit from treatments targeting this defect, including platinum compounds and PARP inhibitors. Abstract Purpose: The elevated levels of somatic copy-number alterations SCNAs in a subset of high-risk endometrial cancers are suggestive of defects in pathways governing genome integrity.

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Friends is currently examining sources of variability across HRD tests and identifying opportunities for alignment while proposing solutions to improve agreement in the future. Historically, cancer treatment involved and relied on chemotherapy, which attacks dividing cells throughout the body, including many cells that are not cancerous. In recent years, scientific innovation has allowed for the safe and effective use of targeted therapies, which can precisely attack cancer cells that have specific signals known as biomarkers, potentially providing more effective and safer treatments for patients. Since not all cancer cells have specific biomarkers targetable by current therapies, it is necessary to identify which patients have the biomarker and may benefit from specific targeted therapies. To help identify which patients have a specific biomarker, diagnostic developers have created tests, also known as assays. Test developers have different approaches for how they identify a specific biomarker increasing variability across results from different tests. One such biomarker facing issues with harmonization is homologous recombination deficiency HRD , which is used to determine which patients with certain types of cancer should be treated with a drug called a PARP inhibitor. A combination of factors is used to determine HR status, and different assays, or tests, use different approaches. This lack of harmonization can make it challenging for patients and providers to interpret the results of these tests. During the first phase of the project, the group conducted a landscape analysis of how HRD is used and defined to establish a baseline understanding of inconsistencies across tests and to propose common terminology.

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Toon meer Toon minder. Uhlhorn, and F. Vergelijk artikelen Waar wil je dit mee vergelijken? Overige kenmerken Doelgroep Dames. Lorsolo, AIR A. Let op: Valt groot uit! Stuur mij een bericht Je hoort van ons. DeHart, University of Washington Objectives: Investigate impact of environmental flow, in particular vertical shear, on tropical cyclone inner-core structure, using a combination of case studies and compositing techniques on a variety of observational and modeling datasets. Klotz, T. Back to Main Projects Page. Hazelton, Florida State University R.

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Principal Investigators: Paul D. Paper documenting this work is under review at JAS. Investigate wind speed asymmetries and their relationship with storm motion and vertical shear using composites of SFMR and flight-level data. This work is being done in collaboration with Mr. Marks, Jr. Zhang, J. Ik wil melding doen Verder winkelen. Environmental flow impacts on tropical cyclone inner-core structure Principal Investigators: Paul D. Vergelijk artikelen Waar wil je dit mee vergelijken? Toon meer Toon minder. Vukicevic, P.