Free radic biol med

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Free Radical Biology and Medicine is a peer-reviewed scientific journal and official journal of the Society for Redox Biology and Medicine. The journal covers research on redox biology, signaling, biological chemistry and medical implications of free radicals , reactive species, oxidants and antioxidants. This article about a biochemistry journal is a stub. You can help Wikipedia by expanding it. See tips for writing articles about academic journals. Further suggestions might be found on the article's talk page.

Free radic biol med

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Tools Tools. Year SJR 1. All types of documents are considered, including citable and non citable documents.

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The discovery of vitamin E will have its th anniversary in , but we still have more questions than answers regarding the biological functions and the essentiality of vitamin E for human health. Discovered as a factor essential for rat fertility and soon after characterized for its properties of fat-soluble antioxidant, vitamin E was identified to have signaling and gene regulation effects in the s. In the same years the cytochrome P dependent metabolism of vitamin E was characterized and a first series of studies on short-chain carboxyethyl metabolites in the s paved the way to the hypothesis of a biological role for this metabolism alternative to vitamin E catabolism. Recent findings are consistent with gene regulation and homeostatic roles of these metabolites in different experimental models, such as inflammatory, neuronal and hepatic cells, and in vivo in animal models of acute inflammation. Molecular mechanisms underlying these responses are under investigation in several laboratories and side-glances to research on other fat soluble vitamins may help to move faster in this direction.

Free radic biol med

Extensive research during the past 2 decades has revealed the mechanism by which continued oxidative stress can lead to chronic inflammation, which in turn could mediate most chronic diseases including cancer, diabetes, and cardiovascular, neurological, and pulmonary diseases. Activation of these transcription factors can lead to the expression of over different genes, including those for growth factors, inflammatory cytokines, chemokines, cell cycle regulatory molecules, and anti-inflammatory molecules. How oxidative stress activates inflammatory pathways leading to transformation of a normal cell to tumor cell, tumor cell survival, proliferation, chemoresistance, radioresistance, invasion, angiogenesis, and stem cell survival is the focus of this review. Overall, observations to date suggest that oxidative stress, chronic inflammation, and cancer are closely linked.

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This indicator counts the number of citations received by documents from a journal and divides them by the total number of documents published in that journal. Free radicals biology. Toggle limited content width. Tools Tools. All types of documents are considered, including citable and non citable documents. This article does not cite any sources. The SJR is a size-independent prestige indicator that ranks journals by their 'average prestige per article'. Article Talk. Cites Year Value External Cites per document 4. Unsourced material may be challenged and removed. Year SJR 1. Please help improve this article by adding citations to reliable sources. Elsevier Netherlands. Further suggestions might be found on the article's talk page.

Cardiovascular diseases CVD , including ischemic heart diseases and cerebrovascular diseases, are the leading causes of morbidity and mortality worldwide. Atherosclerosis is the major underlying factor for most CVD.

Join the conversation about this journal. Publisher Elsevier Inc. Contents move to sidebar hide. This indicator counts the number of citations received by documents from a journal and divides them by the total number of documents published in that journal. Hidden categories: Articles lacking sources from October All articles lacking sources Articles with short description Short description is different from Wikidata Biweekly journals infobox Articles with outdated impact factors from Pages using infobox journal with unknown parameters All stub articles. How to publish in this journal. Impact factor. The chart shows the ratio of a journal's documents signed by researchers from more than one country; that is including more than one country address. SJR is a measure of scientific influence of journals that accounts for both the number of citations received by a journal and the importance or prestige of the journals where such citations come from It measures the scientific influence of the average article in a journal, it expresses how central to the global scientific discussion an average article of the journal is. This article does not cite any sources. Unsourced material may be challenged and removed. Free radicals biology. Article Talk.