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Background: Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Diagnostic criteria for the syndrome were published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS. Objectives: To analyze various types of PNS, frequent tumor and antibody associations, clinical characteristics of individual syndromes, and possible therapeutic and prognostic strategies. Design: Prospective case series and database study. Setting: Twenty European centers. Patients Patients were recruited from January 1, , to December 31,

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Arch Neurol. Background Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Diagnostic criteria for the syndrome were published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS. Objectives To analyze various types of PNS, frequent tumor and antibody associations, clinical characteristics of individual syndromes, and possible therapeutic and prognostic strategies. Patients Patients were recruited from January 1, , to December 31, Main Outcome Measures Based on diagnostic criteria published by the PNS Euronetwork consortium, clinical characteristics of classic PNS and several other less well-characterized syndromes associated with cancer were assessed. Results Data from patients were analyzed, representing the largest PNS investigation to date. The findings elucidate the clinical evolution of paraneoplastic cerebellar syndrome according to the onconeural antibodies present, the heterogeneity and prognosis of dysautonomic disorders, and the clinical variability of paraneoplastic limbic encephalitis. Conclusion The study results confirm that PNS influences oncologic patient survival. Tumors are the main cause of death, but some types of PNS such as dysautonomia have a poorer prognosis than malignant neoplasms. Paraneoplastic neurologic syndrome PNS can affect any part of the nervous system.

Create a personal account or sign in to:. Levine SM Cancer and myositis: euronetwork insights into an old association, euronetwork. Recommended diagnostic criteria for paraneoplastic neurological syndromes.

Background and purpose: To describe the characteristics of patients presenting a paraneoplastic cerebellar degeneration without classical onconeural antibodies seronegative PCD. No significant difference between the clinical characteristics of seronegative and seropositive PCD patients was observed. Yet the frequency of associated tumors was different. Seronegative and seropositive PCD patients with similar tumors had a similar overall survival. Conclusion: The clinical characteristics of seronegative and seropositive PCD are similar but the spectrum of associated tumors is different. The immunological scenario of seronegative PCD seems to be different from that of limbic encephalitis with only few patients harboring anti-neuropile antibodies. Keywords: onconeural antibodies; paraneoplastic cerebellar degeneration.

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Rent article Rent this article from DeepDyve. Analyses were performed using commercially available statistical software SAS, version 9. Patients Patients were recruited from January 1, , to December 31, A remarkable finding was the poor prognosis of patients with dysautonomia; a tumour was found in 37 out of 51 cases and in 28 of these the diagnosis followed the neurological syndrome with a median time of 4. Create a personal account or sign in to:. There were no reported cases of poliomyositis. All participating centers enrolled their patients according to the Graus criteria between January 1, , and December 31, Confirmation statement Next statement date 14 December due by 28 December Last statement dated 14 December Based on the assumption that PNS represents immune-mediated disorders, several therapies were used, including corticosteroids, high-dose immunoglobulins, and plasma exchange. The most frequent combinations were limbic encephalitis associated with dysautonomia 8 patients , with PCD 6 patients , and with Lambert-Eaton myasthenic syndrome 5 patients. The antibody types were within the spectrum for onconeural antibodies and in association with PNS have significant diagnostic value for an underlying cancer. Administrative, technical, and material support : Giometto, Grisold, and Bertolini. Background Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system.

Arch Neurol.

Paraneoplastic stiff person syndrome was characterized by rigidity of limbic muscles in 6 patients and of axial muscles in 3 patients. Paraneoplastic cerebellar degeneration associated with antineuronal antibodies: analysis of 50 patients. Analysis and interpretation of data : Giometto, Grisold, Honnorat, and Bertolini. Anti-Hu—associated paraneoplastic encephalomyelitis: analysis of patients. Hematologic diseases were much less prevalent than solid tumors, with PNS occurring in association with lymphomas in 58 patients 31 with non-Hodgkin lymphoma and 27 with Hodgkin lymphoma. Log in. Finding 2 patients with Parkinson disease one with progressive supranuclear palsy and the other with dystonia might again be a chance association. This confirms that PNS most frequently manifests in cancers with limited disease spread. Outcome status was available in patients Go to my data extractions. Access your subscriptions. Create a personal account or sign in to:. View Metrics. For statistical analysis, proportion was used as a descriptive statistic for categorical and ordinal variables, the median and interquartile range for ordinal and continuous variables, and the mean SD for continuous variables. Thirty-two patients died, including 18 of PNS, 6 of tumor progression, 4 of other causes, and 4 of unknown cause Table 6.