Basolateral membrane

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Basolateral membrane

Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. The major function of epithelial tissues is to maintain proper ion, solute, and water homeostasis. The tubule of the renal nephron has an amazingly simple structure, lined by epithelial cells, yet the segments i. The functional differences are because epithelial cells are polarized and thus possess different patterns distributions of membrane transport proteins in the apical and basolateral membranes of the cell. Mutations of these channels can cause significant disease. Transepithelial transport is not a simple feat; rather it is a well-orchestrated physiological process involving numerous membrane transport proteins. Epithelial cells are polarized and thus possess different patterns distributions of membrane transport proteins in the apical and basolateral membranes of the cell depending upon the specific function of a given epithelium , The human genome project has led to the identification of numerous additional ion transport proteins at the molecular level. These include various renal tubulopathies, including Bartter's syndrome 42 , 64 , , Gitelman's syndrome 37 , 88 , EAST syndrome for infant E pilepsy, severe A taxia, moderate S ensorineural deafness and renal salt wasting T ubulopathy 2 , 11 , SeSAME syndrome for Se izures, S ensorineural deafness, A taxia, M ental retardation and E lectrolyte imbalance , , , Liddle's disease 14 , , nephrogenic diabetes insipidus 10 , 80 , and renal tubular acidosis syndrome Cellular model of a polarized epithelial cell. Potassium channels are present within all cells of the body.

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Epithelial polarity is one example of the cell polarity that is a fundamental feature of many types of cells. Epithelial cells feature distinct 'apical', 'lateral' and 'basal' plasma membrane domains. Epithelial cells connect to one another via their lateral membranes to form epithelial sheets that line cavities and surfaces throughout the animal body. Each plasma membrane domain has a distinct protein composition, giving them distinct properties and allowing directional transport of molecules across the epithelial sheet. How epithelial cells generate and maintain polarity remains unclear, but certain molecules have been found to play a key role.

Most recent articles on Basolateral membrane. Most cited articles on Basolateral membrane. Review articles on Basolateral membrane. Powerpoint slides on Basolateral membrane. Images of Basolateral membrane. Photos of Basolateral membrane. Videos on Basolateral membrane. Cochrane Collaboration on Basolateral membrane. Bandolier on Basolateral membrane.

Basolateral membrane

Bacteria in Biology, Biotechnology and Medicine 5th ed. New York: Wiley. New York: Garland Science. ISBN December 29, Journal of the American Chemical Society 2 : — PMC PMID Biology Direct 9 : ISSN

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J Cell Biol. Garland Science. Basolateral membrane potassium channels in rabbit cortical thick ascending limb. Ookata et al. Additionally, SLO2. How epithelial cells adopt particular shapes is poorly understood, but it must involve spatial control of the actin cytoskeleton , which is central to cell shape in all plant cells. Address for reprint requests and other correspondence: K. In the fruit fly Drosophila melanogaster , Cdc42 is recruited by the aPKC complex and then promotes the apical localization of the aPKC complex in a probable positive feedback loop. With a view of these results coupled together, EAST syndrome patients would exhibit compromised reabsorptive capacity of DCT cells based on morphology and channel function Review articles on Basolateral membrane. Pearse BM: Receptors compete for adaptors found in plasma membrane coated pits. Conversely, in the absence of any of Lgl, Dlg or Scrib, the apical determinants spread into the former baso-lateral domain.

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Further studies will be required to explore the individual functions of specific signal types, as well as the roles for oligomerization and for hierarchical and cooperative interplay in determining the mechanisms through which complex signals are interpreted. Spodsberg N, Alfalah M, Naim HY: Characteristics and structural requirements of apical sorting of the rat growth hormone through the O-glycosylated stalk region of intestinal sucrase-isomaltase. Identification of a basolateral targeting domain. Lipardi C, Nitsch L, Zurzolo C: Detergent-insoluble GPI-anchored proteins are apically sorted in fischer rat thyroid cells, but interference with cholesterol or sphingolipids differentially affects detergent insolubility and apical sorting. Bartter syndromes and other salt-losing tubulopathies. Aquaporin 2 mutations in nephrogenic diabetes insipidus. Potassium channels in renal epithelial transport regulation. Cell 71 : —, [ PubMed ] [ Google Scholar ]. In contrast, Brochiero et al. Mechanisms and significance of cell volume regulation.