Alpha inhibin

Click here to buy online! Inhibins are peptide hormones produced by the granulosa cells in female follicles and by Sertoli cells in the male seminiferous tubules. They are selectively expressed by cells of sex-cord stromal alpha inhibin, and inhibit the secretion of follitropin by the pituitary gland, alpha inhibin. Inhibin contains an alpha and beta subunit linked by disulfide bonds.

Federal government websites often end in. The site is secure. As a result of its expression in corresponding normal cell types, inhibin alpha INHA is used as an immunohistochemical marker for adrenocortical neoplasms and testicular or ovarian sex cord stromal tumors. However, other tumors can also express INHA. To comprehensively determine INHA expression in cancer, a tissue microarray containing 15, samples from different tumor types and subtypes was analyzed by immunohistochemistry. In summary, these data support the use of INHA antibodies for detecting sex cord stromal tumors, granular cell tumors, and adrenocortical neoplasms.

Alpha inhibin

Inhibin is a peptide hormone that is produced by ovarian granulosa cells which inhibits the release of Follicle-Stimulating Hormone FSH. The Inhibin alpha antibody subunit is expressed in a wide range of human tissues outside the reproductive axis such as prostate, brain, adrenal, as well as in the granulosa cells of the ovary, Sertoli cells of the testis and various cells of the fetoplacental unit. Inhibin may be used as a differential marker for adrenocortical tumors, placenta and gestational trophoblastic lesions and sex cord stromal tumors. Normal testis or normal ovary, adrenal gland. Groome, N G et al Monoclonal and polyclonal antibodies reactive with the amino terminal sequence of the alpha subunit of human 32K inhibin. Hybridoma 9 1 : 2. Groome, N G et al Preparation of monoclonal antibodies to beta A subunit of ovarian inhibin using a synthetic peptide immunogen. Hybridoma 10 2 : 3. Journal of Pathology 4. McCluggage WG. Recent advances in immunohistochemistry in the diagnosis of ovarian neoplasms. J Clin Pathol May;53 5 5. Center for Disease Control Manual. Guide: Safety Management, NO. Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline.

Tumors of the urinary system. Answers B, alpha inhibin, C and D are incorrect because inhibin staining is most often negative in soft tissue neoplasms like liposarcomas, schwannomas and neurofibromas and may only be useful as part of an antibody panel in very limited cases. You may also like.

It appears that your browser has cookies disabled. The website requires your browser to enable cookies in order to login. Don't have a login? Register today to view list prices and apply for an account to purchase online! Inhibins and activins play a role in the regulation of pituitary follicle stimulating hormone FSH secretion. The actions of inhibins and activins are thought to oppose one another, with inhibins suppressing FSH secretion and activins stimulating FSH secretion. Inhibins are secreted by granulosa cells in female follicles and Sertoli cells of the testis in the male.

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Alpha inhibin

The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it. Contents move to sidebar hide. Article Talk. Read Edit View history. Tools Tools.

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Editorial Board Member: Christian M. No item added to cart The replacement product is no longer available, no item has been added to cart. This Website requires your browser to be JavaScript enabled. Andreas H. Genome Biol. Freshly cut TMA sections were immunostained on one day and in one experiment. CW and expression of bone morphogenetic protein 2 in Japanese patients with granulosa cell tumor of ovary. Inhibin is a peptide hormone that is produced by ovarian granulosa cells which inhibits the release of Follicle-Stimulating Hormone FSH. Skip to content. Human testis: immunohistochemical staining for inhibin alpha showing cytoplasmic staining of Sertoli cells. They are selectively expressed by cells of sex-cord stromal derivation, and inhibit the secretion of follitropin by the pituitary gland. Prognostic factors. Small cell neuroendocrine carcinoma of the bladder.

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Safety Data Sheet. Sex cord-stromal tumors of the ovary and testis: Their similarities and differences with consideration of selected problems. Elevations of both inhibin subunits have been detected in GCT Inhibin beta may be a tumor marker for determining response to therapy in GCT Clin Endocrinol Oxf ; Mutations in the inhibin gene are associated with premature ovarian failure caused by a reduction in inhibin beta Hum Reprod Update ; Serum levels of both inhibin subunits may be useful when assessing ovarian function in patients with Turner syndrome Pol Merkur Lekarski ; Serum levels of inhibin alpha are part of a quadruple test for prenatal screening of Down syndrome Semin Reprod Med Inhibin alpha Inhibin beta Folliculostatin. Inhibin may be used as a differential marker for adrenocortical tumors, placenta and gestational trophoblastic lesions and sex cord stromal tumors. Inhibin is a useful marker to differentiate GCT from other epithelial neoplasms with similar histology; inhibin staining in other epithelial neoplasms is usually weak or negative and limited to nontumoral stromal theca cells Rom J Morphol Embryol ; Nucleic Acids Res. Biopsy, ovary: Granulosa cell tumor see comment Comment: A 60 year old woman presented with abnormal uterine bleeding and abdominal pain. Genes Chromosom. Inhibin contains an alpha and beta subunit linked by disulfide bonds. Learn how your comment data is processed. The panels show a cytoplasmatic INHA immunostaining of variable intensity in samples from a granulosa cell tumor of the ovary A , a Leydig cell tumor B and Sertoli cell tumor of the testis C , an adrenocortical carcinoma D , a granular cell tumor from the floor of mouth E , and a clear cell carcinoma of the kidney F. Uses by pathologists. As a library, NLM provides access to scientific literature.