Acinus pancreas

Acini and Centro-acinar Cells. The exocrine pancreas is a compound gland consisting of secretory endpieces acini draining into a converging duct system [5,17,30]. The acini, hilti каталог 2016 are composed of cells that synthesise digestive enzymes and store them as zymogen granules, are found at the terminations of the intercalated ducts, but also, in some species, at intermediate points along the ducts, so that an acinus may surround an intercalated duct part way along its course. In most species, the individual cells form truncated acinus pancreas so that, when they are aggregated to form a secretory endpiece, acinus pancreas, the endpiece is acinus pancreas like a berry Latin: acinus rather than being tubular [64].

The pancreatic acinar cell is the functional unit of the exocrine pancreas. It synthesizes, stores, and secretes digestive enzymes. Under normal physiological conditions, digestive enzymes are activated only once they have reached the duodenum. Premature activation of these enzymes within pancreatic acinar cells leads to the onset of acute pancreatitis; it is the major clinical disorder associated with pancreatic acinar cells. Although there have been major advances in our understanding of the pathogenesis of this disease in recent years, available treatment options are still limited to traditional nonspecific and palliative interventions. Novel therapeutic strategies have been suggested based on ongoing research in the physiology and pathophysiology of the disease; these include the administration of systemic antibiotics, antioxidants, cytokine antagonists, and more recently, inhibition of the renin-angiotensin system.

Acinus pancreas

Federal government websites often end in. The site is secure. A pancreatic acinus is a functional unit of the exocrine pancreas producing digest enzymes. Its pathobiology is crucial to pancreatic diseases including pancreatitis and pancreatic cancer, which can initiate from pancreatic acini. However, research on pancreatic acini has been significantly hampered due to the difficulty of culturing normal acinar cells in vitro. In this study, an in vitro model of the normal acinus, named pancreatic acinus-on-chip PAC , is developed using reprogrammed pancreatic cancer cells. In this model, human pancreatic cancer cells, Panc-1, reprogrammed to revert to the normal state upon induction of PTF1a gene expression, are cultured. Bioinformatic analyses suggest that, upon induced PTF1a expression, Panc-1 cells transition into a more normal and differentiated acinar phenotype. The microanatomy and exocrine functions of the model are characterized to confirm the normal acinus phenotypes. The developed model provides a new and reliable testbed to study the initiation and progression of pancreatic cancers. The pancreas is a large gland organ performing two distinct functions in the digestive system.

Finally, biotinylated Avidin-Alexa Fluor cat. ACC are typically large, up to 10 cm, and soft compared to pancreatic adenocarcinoma, lacking its dense stroma. As a library, NLM provides access to scientific literature, acinus pancreas.

Acinar cell carcinoma of the pancreas , also acinar cell carcinoma , is a rare malignant exocrine tumour of the pancreas. It typically has a guarded prognosis. The disease is more common in men than women and the average age at diagnosis is about ACC is associated with increased serum lipase and manifests in the classic presentation known as the Schmid triad subcutaneous fat necrosis , polyarthritis, eosinophilia. ACC are typically large, up to 10 cm, and soft compared to pancreatic adenocarcinoma, lacking its dense stroma. They can arise in any part of the pancreas.

Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. This review identifies and puts into context the recent articles which have advanced understanding of the functions of pancreatic acinar cells and the mechanisms by which these functions are regulated. Receptors present on acinar cells, particularly those for cholecystokinin and secretin, have been better characterized as to the molecular nature of the ligand-receptor interaction.

Acinus pancreas

The pancreas is an abdominal organ located deep in the retroperitoneum. It is a gland with mixed function: both exocrine and endocrine. In this article, we will consider just the exocrine functions of the pancreas, the synthesis of pancreatic enzymes and the regulation of enzyme secretion. Finally, we will consider the clinical relevance of the pancreatic exocrine functions. When we consider the functions of the pancreas, it is simpler to view it as a mix of two glands. We can divide the pancreas into an exocrine gland, containing the acinar and duct tissue, and the endocrine gland containing the islets of Langerhans. The bicarbonate helps in neutralising the stomach acid. This is a vital part of digestion as the small intestine is not specialised to withstand the strong acids from the stomach.

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This reprogrammable cancer cell line was developed based on a prior study showing that in the healthy pancreas, the basic helix—loop—helix transcription factor PTF1a regulates an acinar-specific transcription network suppressing a transformative process of acinar—ductal metaplasia. Am J Surg Pathol. Toxicol , , 34 , e The difficulty to microscopically access the acinus for the detailed study is another drawback. Toggle limited content width. Although the PTF1a level in 2D induction is higher than that in 3D induction, the induction of PTF1a consistently leads to acinus phenotypes regardless of the induction and loading sequence. First published 09 Aug Clin , , 69 , 7— Biol , , 36 , — Moreover, no notable differences are observed in growth morphology see Fig. From the journal: Lab on a Chip. Korean J Gastroenterol.

The pancreas is surrounded by a very thin connective tissue capsule that invaginates into the gland to form septae, which serve as scaffolding for large blood vessels.

Publisher Name : Springer, Berlin, Heidelberg. The disease is more common in men than women and the average age at diagnosis is about However, research on pancreatic acini has been significantly hampered due to the difficulty of culturing normal acinar cells in vitro. Acinar cavity is present at the apical side. Bumsoo Han. As shown in Fig. The developed model provides a new and reliable testbed to study the initiation and progression of pancreatic cancers. Buying options Chapter EUR Sorry, a shareable link is not currently available for this article. Pancreatitis is an inflammation of the pancreas, in which the digestive enzymes digest the pancreas itself. Although the PTF1a level in 2D induction is higher than that in 3D induction, the induction of PTF1a consistently leads to acinus phenotypes regardless of the induction and loading sequence.